Florence is an Italian city located in the center of the Tuscany region. Florence was the birthplace of the Italian Renaissance and is famous for its architecture and art. Galileo, Michelangelo, and Dante all have monumental tombs in Florence. The city is known for its Fountain of Neptune, the Ponte Vecchio Bridge, San Lorenzo Palace, the Uffizi Art Gallery, and most famously for the Santa Maria del Fiore, a domed cathedral. Located on the Arno River, Florence has a population of 400,000.