I've been on the patch for 2 years and have had no problems at all. I got my libido back (after feeling numb from the pills for years) and I don't feel moody or anything. The only problem I've noticed is since I started training for a marathon and running up to 15-16 miles at a time, the skin under the patch becomes extremely itchy and painful. I tore the patch off to relieve myself and it looked like red puffy paint! I now have scabbs there from a week and a half ago. I asked the doctor who told me that running that much increases the circulation in my legs which makes the dosage from the patch increase. Scary... I'm not contemplating changing to the Nuva ring, but I'm not sure about that either. Overall though, until this new development with running, I had no problems at all. The patch stays put and I feel fine!