Every baby is different. This review is based on my own personal experience and I do not claim to speak for anybody else.My son was given Similac when he was born but he was gassy with it so I thought that Nestle would be a better choice. It had the "comfort proteins" and they made it sound as though nothing would be easier on his little tummy. My son HATED this formula. While he was on it he had terrible gas and cramps and would wake up in the middle of the night crying from the gas pressure. He was also spitting up quite frequently with it. I, like other reviewers, found that it didn't dissolve very well. No matter how hard you shook it, there were still undissolved pieces in it. I finally had enough and switched to Enfamil Gentlease and have had no problems with either gas or spitting up since. Ultimately, it is a trial and error process and what works for one baby will not for another.