Here's the kind of messages I routinely ignore:
Obvious sales pitches,
Whiny messages from my ex, that are not related to our kids,
Chain e-mails,
Cattle-call emails or auto-dialed messages ("you have been selected as a special guest of..."),
Reminder payment calls from my cell provider, credit card, etc.,
And any message from a small but select number of folks I just don't want to talk to.