I have only just started using duac last night. During the night I woke up and have had no sleep as my face is extremely sore and warm and itchy. Today my face is swollen and extremely red and puffy and this discomfort is not worth it, I would rather go back to having my skin before I put this on than being in such pain, it really hurts. Ii have also had terrible reactions with panoxyl. I guess I have become extremely sensitive to these creams, so I don't know what to do now. I don't know whether to wait and put a tiny bit on tomorrow if this has calmed down as my doctor said to keep with it and after two weeks irritation should go. But I wouldn't call this irritation, I call this severe reaction, I've been on so many creams for four years and right now I just feel like giving up.