I think everyone here needs to realise that all types of medication can affect different people in different ways, and you never know until you try it. I've been on Depo for 5 years and I think it's the best thing ever. I used to get really bad PMS and got really suicidal and had unbearable pain and puking every time I got my period. Then I went on the pill, put on weight, and got even more suicidal. The main difference was that I tried to kill myself precisely every 28 days. So I went on Depo, I haven't had a period since, which is fantastic (it's not like they improve your life, right?), don't get PMS, my moods are much more stable than they ever were before, and I only put on weight at xmas when my BF's mum gives us about a ton of chocolate. There is a risk of loss of bone density, but if you get plenty of calcium and vitamin D you'll be fine. I see that as a minor risk compared to the risk that I'll kill myself or get pregnant. I love it, it's really convenient and has made my life so much easier. Anyone who has got side effects such as dryness, headaches, mood swings, loss of sexual desire, etc., are you on any other medications? Lots of things cause those symptoms, especially antidepressants, and most especially Prozac, which is one of the most evil drugs ever invented.