When i first started using duac, i would wake up in the morning with what looked and felt like red, sunburnt raw skin. It was quite painful, but i was determined to get the contiuous white-headed spots which were always spreading and mulitplying across my cheeks away for good. I talked to a friend who also have been prescribed with duac and she confirmed similar reactions to the gel, yet we concluded the daily face wash and perhaps moisturisers we were using were adding to the irritation. At the time i was using a clearasill 3-in wash with microbeads. It was strong and always left my skin tingling after use, so when i cut it out the duac results appeared withing 1-2 weeks. Keeping it stored in the fridge over the first couple of days DOES HELP. its cooler when you apply so if your skin is red, it eases it slightly. Also if your skin in DRY, but still spotty, sometimes i mix hyrdrocortosone and duac together and rub that over the infected area and it helps alot! Use at night!!