I have rosacea acne of which has been getting worse lately. The doc put me on duac cream, and minocyline pills. I use duac on my face for the first time two days ago. Just one application and my face is still beat red, puffy, itching horribly, stinging, and hot to the touch.Even my lips are puffy! I had some bad pimples just below my jaw line, and the duac cause all these symptoms to spread to the bottom of my neck! By what I am reading here, it seems that some people can use this product and some cannot. Obviously I am one of the unlucky ones that cannot. I am afraid to use it again. And yes it is very expensive. I wish I could find something that would work :(